Accounting for Dependencies in Deep Learning Based Multiple Instance Learning for Whole Slide Imaging
نویسندگان
چکیده
Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions pixels, which create enormous computational and annotation challenges. Typically, such are divided into set patches (a bag instances), where only bag-level class labels provided. Deep based MIL methods calculate features using convolutional neural network (CNN). Our proposed approach also deep based, with the following two contributions: Firstly, we propose to explicitly account dependencies between instances during training by embedding self-attention Transformer blocks capture instances. For example, tumor grade may depend on presence several particular patterns at different locations in WSI, requires patches. Secondly, an instance-wise loss function pseudo-labels. We compare multiple baseline methods, evaluate it PANDA challenge dataset, largest publicly available WSI dataset over 11K images, demonstrate state-of-the-art results.
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ژورنال
عنوان ژورنال: Lecture Notes in Computer Science
سال: 2021
ISSN: ['1611-3349', '0302-9743']
DOI: https://doi.org/10.1007/978-3-030-87237-3_32